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Chiral Separation of Propranolol Enantiomers by Oxidized Multiwalled Carbon Nanotubes/β-cyclodextrin Impregnated Thin-layer Chromatography

[ Vol. 10 , Issue. 2 ]


Xiao-Qing Chen, Cong-Hao Sun, Fei-Peng Jiao, Jin-Gang Yu and Xin-Yu Jiang   Pages 267 - 270 ( 4 )


Extremely good enantioseparation of a kind of commonly used β-blockers, (±)-propranolol, has been achieved on silica gel layers which were impregnated with β-cyclodextrin and oxidized multi-walled carbon nanotubes. Solvent system tert-butenol-acetonitrile (1:1, v/v) successfully resolved the enantiomers of (±)-propranolol. The spots were detected at 254 nm with a UV lamp. The effect of concentration of the mobile phase variation was also studied.


Enantioseparation, propranolol, β-cyclodextrin, oxidized multi-walled carbon nanotubes, thin-layer chromatography.


College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China.

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