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Comprehensive Determination of Pharmaceuticals, Personal Care Products, Benzotriazole UV Stabilizers and Organophosphorus Flame Retardants in Environmental Water Samples Using SPE Coupled with UHPLC-MS/MS

[ Vol. 11 , Issue. 2 ]


Joon-Woo Kim, Tomohiko Isobe, Rumi Tanoue, Kwang-Hyeon Chang and Shinsuke Tanabe   Pages 138 - 149 ( 12 )


A high throughput and sensitive analytical method for the comprehensive determination of 31 environmental contaminants (10 pharmaceuticals and personal care products, PPCPs; 8 benzotriazole UV stabilizers, BUVSs; and 13 organophosphorus flame retardants and plasticizers, PFRs) in aqueous sample using solid phase extraction (SPE) followed by ultra-high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) was developed. The optimized method was applied to aqueous samples and the limits of quantification (LOQs) ranged from 1.9 to 16 ng L-1 and from 2.3 to 45 ng L-1 in river water and effluent of sewage treatment plant (STP), respectively. All the correlation coefficients of the calibration curves were equal or greater than 0.99 in the range of 0.01-10 μg L-1. Oasis HLB (60 mg) cartridge showed the highest recoveries for all the analytes in river water (71- 115%) as well as in wastewater (71-117%) except for dibenzyl phosphate (DBzP) (58%). The intra- and inter-day repeatabilities were less than 14% at the two spiked levels (100 and 500 ng L-1). The developed method was applied for the determination of these target compounds in river water and STP effluent collected from Kumamoto, Suya and Matsuyama, Japan. Of the thirty-one compounds monitored, seventeen were found in one or more samples, especially diclofenac (DF) and carbamazepine (CBZ) were detected in all the water samples.




Center for Environmental Health Sciences, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506, Japan.

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