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A Novel Multi-functional Fluorescent Probe for Cu2+, Fe3+ and Ag+ Based on a Pyrimidine Thiourea Derivative

[ Vol. 11 , Issue. 4 ]


Hassan H. Hammud, Mohammad H. El-Dakdouki, Nada Sonji, Ghassan Sonji and Kamal H. Bouhadir   Pages 279 - 290 ( 12 )


A multi-functional “turn-off” fluorescent probe, N-[[(6-Amino-1,2,3,4-tetrahydro-1,3- dimethyl-2,4-dioxo-5-pyrimidinyl)amino]thioxomethyl]- benzamide, was synthesized and characterized. The probe showed high sensitivity and selectivity towards copper(II), iron(III) and silver(I) ions via quenching of its fluorescence. The detection limits were found to be 4.0 – 16.0 ppb for the assayed cations. The thiourea linked uracil fluorescent probe is proved to be sensitive, selective, applicable in real samples and promise for practical applications.


5, 6-diamino-1, 3-dimethyluracil, fluorescent probe, silver, ferric, cupric ion, sensor.


Department of Chemistry, Faculty of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia., Department of Chemistry, Faculty of Arts and Sciences, American University of Beirut, Beirut, Lebanon.

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