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Prepare and Assessment of a New Purity Certified Reference Material of Quercetin

[ Vol. 13 , Issue. 2 ]

Author(s):

Ningbo Gong, Guimin Jin, Zhaolin Gao, Guanhua Du and Yang Lu   Pages 111 - 116 ( 6 )

Abstract:


Objective: The aim of this study was to prepare and certify a new Certified Reference Material (CRM) of quercetin for the quality control of quercetin and related functional foods and botanical supplements.

Methods: Three different methods, including coloumetric titration (CT), differential scanning calorimetry (DSC) and mass balance (MB) methods were used in the purity determining process.

Results: The purity results determined by the three methods were consistent, and the CT has the highest accuracy and the smallest uncertainty.

Conclusion: CT and DSC methods were established for purity determination of quercetin for the first time. The purity of quercetin CRM, after validation and evaluation, was 99.3% ± 0.4% (k = 2, P = 0.95). The new CRM can be widely used to quantitatively analyse quercetin and other related functional foods and botanical supplements.

Keywords:

Quercertin, certified reference material, CT, DSC, mass balance method, functional foods.

Affiliation:

Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Shandong Key laboratory of Polymorphic Drugs, Tengzhou, Shandong, 277500, Beijing Key Laboratory of Drug Targets and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

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