Ali Samadzadeh, Iran Sheikhshoaie* and Hassan Karimi-Maleh* Pages 166 - 171 ( 6 )
Background: Simultaneous analysis of epinephrine and tyrosine as two effective and important biological compounds in human blood and urine samples are very important for the investigation of human health.
Objective: In this research, a highly effective voltammetric sensor fabricated for simultaneous analysis of epinephrine and tyrosine. The sensor was fabricated by the modification of glassy carbon electrode with ZnO-Pt/CNTs nanocomposite (ZnO-Pt/CNTs/GCE). The synthesized nanocomposite was characterized by SEM method. The ZnO-Pt/CNTs/GCE showed two separated oxidation signals at potential ~220 mV and 700 mV for epinephrine and tyrosine, respectively. Also, we detected linear dynamic ranges 0.5-250.0 µM and 1.0-220 µM with a limit of detections 0.1 µM and 0.5 µM for the determination of epinephrine and tyrosine, respectively. The ZnO-Pt/CNTs/GCE was used for the determination of epinephrine and tyrosine in blood serum and human urine samples.
Epinephrine, tyrosine, ZnO-Pt/CNTs nanocomposite, electrochemical sensors, carbon electrode, biological compounds.
Department of Chemistry, Shahid Bahonar University, Kerman, Department of Chemistry, Shahid Bahonar University, Kerman, Department of Chemical Engineering, Laboratory of Nanotechnology, Quchan University of Technology, Quchan