Sarfaraz Ahmed Mahesar*, Saeed Ahmed Lakho, Syed Tufail Hussain Sherazi, Hamid Ali Kazi, Kamran Ahmed Abro, Razium Ali Soomro and Andrei Bunaciu Pages 198 - 206 ( 9 )
Background: Captopril is the synthetic dipeptide used as an angiotensin converting enzyme inhibitor. Captopril is used to treat hypertension as well as in the treatment of moderate heart failure. Analytical instrumentation and methodology play an important role in pharmaceutical analysis.
Methods: This review presents some important applications of electrochemical modes used for the analysis of captopril. So far captopril has been analyzed by using different bare and modified working electrodes with a variety of modifiers from organic and inorganic materials to various types of nano particles/materials.
Results: This paper presents some of the methods which have been published in the last few years i.e. from 2003 to 2016. This review highlights the role of the analytical instrumentation, particularly electrochemical methods in assessing captopril using various working electrodes.
Conclusion: A large number of studies on voltammetry noted by means of various bare and modified electrodes. Among all of the published voltammetric methods, DPV, SWV, CV and miscellaneous modes were trendy techniques used to analyze captopril in pharmaceutical formulations as well as biological samples. Electrodes modified with nanomaterials are promising sensing tools as this showed high sensitivity, good accuracy with precision as well as selectivity. In comparison to chromatographic methods, the main advantages of electrochemical methods are cheaper instrumentation, lower detection limit and minimal or no sample preparation.
Captopril, electroanalytical techniques, working electrodes, miscellaneous modes, modifiers, hypertension.
National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro-76080, National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro-76080, National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro-76080, Department of Pharmacy, Shah Abdul Latif University, Khairpur- 66111, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Pharmaceutical Research Center, Karachi-75280, National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro-76080, AAB_IRresearch laboratory, 7 Modoran Ene Street, BlM92, apt. 96, Bucharest - 5, 051832