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An Overview on Analytical Methods for Quantitative Determination of Aristolochic Acids


Mohammad Reza Afshar Mogaddam, Adeleh Yadeghari and Abolghasem Jouyban*   Pages 1 - 11 ( 11 )


Background: Aristolochic acids are chemically linked to nitrophenanthrene carboxylic acids which are found in aristolochia plants These compounds are intrinsically carcinogenic, while they have been used in traditional medicine from a long time ago. Despite the beneficial effects of herbals for treating some diseases, they possess some side effects. Methods: Therefore, the development of a sensitive and selective procedure for the determination of these harmful components in various complicated samples is an important task for health systems and drug authorities. In the past years, ultra-pressure liquid chromatography, high performance liquid chromatography and capillary electrophoresis with different detection systems were used for determination of aristolochic acids in various samples. Results: In this review, different analytical methods have been discussed in brief and applications of them in diverse samples have been summarized. Conclusion: Different approaches are compared from point of sensitivity, selectivity, and extraction efficiency.


Aristolochic acids, Capillary electrophoresis, High–performanceliquid chromatography, Ultra–performance liquid chromatography, Sample preparation


Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz

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