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A Sensitive and Selective Electrochemical Sensor for Sulfadimethoxine Based on Electropolymerized Molecularly Imprinted Poly (o-aminophenol) Film


Youyuan Peng* and Qiaolan Ji   Pages 1 - 8 ( 8 )


Background: As a broad-spectrum antibiotic of the sulfonamide family, sulfadimethoxine (SDM) has been widely utilized for therapeutic and growth-promoting purposes in animals. However, the use of SDM can cause residual problems. Even low concentration of SDM in aquatic system can exert toxic effects on target organisms and green algae. Therefore, the quantitation of SDM residues has become an important task.

Methods: The present work describes the development of a sensitive and selective electrochemical sensor for sulfadimethoxine based on molecularly imprinted poly(o-aminophenol) film. The molecular imprinted polymer film was fabricated by electropolymerizing o-aminophenol in the presence of SDM after depositing carboxylfunctionalized multi-walled carbon nanotubes onto a glassy carbon electrode surface. SDM can be quickly removed by electrochemical methods.The imprinted polymer film was characterized by cyclic voltammetry, differential pulse voltammetry and scanning electron microscopy.

Results: Under the selected optimal conditions, the molecularly imprinted sensor shows a linear range from 1.0 × 10-7 to 2.0 × 10-5 mol L-1 for SDM, with a detection limit of 4.0 × 10-8 mol L-1. The sensor was applied to the determination of SDM in aquaculture water samples successfully, with the recoveries ranging from 95% to 106%.

Conclusion: The proposed sensor exhibited high degree of selectivity for SDM in comparison to other structurally similar molecules, along with long term stability, good reproducibility and excellent regeneration capacity. The sensor may offer a feasible strategy for the analysis of SDM in aquaculture water samples.


Multiwalled carbon nanotubes, molecularly imprinted poly(o-aminophenol) film, sulfadimethoxine, electrochemical polymerization


College of Chemical Engineering and Material Sciences, Quanzhou Normal University, Quanzhou 362000, Fujian, College of Chemical Engineering and Material Sciences, Quanzhou Normal University, Quanzhou 362000, Fujian

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