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Advances in Chiral Separations at Nano Level

Author(s):

Al Arsh Basheer, Iqbal Hussain, Marcus Tullius Scotti, Luciana Scotti and Imran Ali*   Pages 1 - 17 ( 17 )

Abstract:


Background: Nano level chiral separation is necessary and demanding in the development of the drug, genomic, proteomic, and other chemical and the environmental sciences. Few drugs exist in human body cells for some days at nano level concentrations, that are out of the jurisdiction of the detection by standard separation techniques. Likewise, the separation and identification of xenobiotics and other environmental contaminants (at nano or low levels) are necessary for our healthiness.

Discussion: This review article reports the state-of-the-art of nano level chiral analyses by nano liquid chromatography (NLC) and nano capillary electrophoresis (NCE). The optimization procedure of the enantiomeric resolution is also deliberated. Also, the efforts are made to describe the chiral resolution mechanisms of in NLC and NCE. Finally, the future perspectives are also emphasized.

Conclusion: This article will be beneficial for chiral chromatographers, academicians, pharmaceutical industries, environmental researchers and Government regulation authorities.

Keywords:

Nano level chiral resolution, Nano Liquid chromatography (NLC) and nano capillary electrophoresis (NCE), Chiral recognition mechanisms, Future perspectives

Affiliation:

State University of New York, Flint Entrance, Amherst, NY 14260 Buffalo, Department of General Studies, Jubail Industrial College, Jubail Industrial City, Jubail, Cheminformatics Laboratory- Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba-Campus I 58051-970, João Pessoa, PB, Teaching and Research Management - University Hospital Cheminformatics Laboratory- Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba-Campus I 58051-970, João Pessoa, PB, Department of Chemistry, College of Sciences, Taibah University, Al-Medina Al-Munawara – 41477



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