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AIE Luminogens as Versatile Bioprobes

[ Vol. 17 , Issue. 3 ]

Author(s):

Moustafa T. Gabr and F. Christopher Pigge*   Pages 302 - 316 ( 15 )

Abstract:


Background: Luminogens that feature aggregation induced emission (AIE) are typically non-emissive in solution but become highly luminescent upon aggregation in poor solvents or solid state.

Discussion: Unlike conventional fluorophores that exhibit aggregation-caused quenching (ACQ), utilization of AIE luminogens as bioprobes has featured superior photostability, low background signal, large Stokes’ shifts, high sensitivity and turn-on luminescent response.

Conclusion: The versatility of AIE-based luminogens as bioprobes has been demonstrated through various applications in cell organelle imaging, ion sensing and sensitive detection of biomacromolecules. Examples of AIE-based luminogens and their applications as luminescent sensors for biosensing and optical imaging are discussed herein.

Keywords:

Aggregation, bioprobes, fluorescence, luminescence, organelle imaging, sensors.

Affiliation:

Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242

Graphical Abstract:



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