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Radiation Sterilization of Antibiotics in Solid State

Author(s):

Karolina Kilińska and Przemysław Zalewski*   Pages 1 - 7 ( 7 )

Abstract:


Radiation sterilization is a promising method of obtaining sterile active pharmaceutical ingredients (API), excipients and formulations. One of the best methods of sterilization is to use ionizing radiation. The greatest advantage of ionizing radiation is fact that can be conducted at room temperature or lower. Therefore this procedure of sterilization is reserved for drugs sensitive to the high temperature of autoclaving. Solutions of parenterally administered antibiotics must be absolutely aseptic. Most of the antibiotics are susceptible for the degradation at increased temperature and humidity so radiation is often used to obtain sterile bactericidal drugs.

Keywords:

Radiation sterilization, cephalosporis, penicillins, fluoroquinolones, carbapenems, aminoglycosides, tertracyclines, sulphonamides, anthracyclines.

Affiliation:

Department of Pharmacognosy, Poznan University of Medical Sciences, Święcickiego 4, 60-781 Poznań, Department of Pharmacognosy, Poznan University of Medical Sciences, Święcickiego 4, 60-781 Poznań



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