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Electrochemical Analysis for Pharmaceuticals by the Advantages of Metal Oxide Nanomaterials

Author(s):

Burcin Bozal-Palabiyik, Cem Erkmen, Sevinc Kurbanoglu, Sibel A. Ozkan and Bengi Usl*   Pages 1 - 18 ( 18 )

Abstract:


Background: Electrochemical methods in drug analysis have a lot of advantages including simplicity, speed, low-cost instrumentation, informing about the drug mechanism, and non-affection by excipients in dosage forms. Electrochemical techniques utilize the advantages of nanomaterials to increase sensitivity and, in some cases, selectivity. Among these nanomaterials, metal oxide nanoparticles are also preferred by researchers because of their unique properties such as biocompatibility, stability, non-toxicity, and catalytic characteristic.

Objective: This review provided a brief information about metal oxide nanoparticles used in electrochemical sensors and summarized applications for drug analysis with these sensors in tables showing the studies in the literature during the last decade.

Results: In the last decade, metal oxides are frequently used in electrochemical drug analysis as electrode modifier individually and with other nanomaterials especially carbon-based ones. All these studies showed that metal oxide nanoparticles increase the active surface area of the electrode and the catalytic activity.

Conclusion: When metal oxide nanoparticles and carbon-based nanomaterials are used together, they create a synergistic effect that further increases catalytic activity and thus lowers detection limits to be obtained in nM even pM levels

Keywords:

Drug analysis, electrochemistry, iron oxide, metal oxide nanoparticles, titanium dioxide, zinc oxide

Affiliation:

Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara



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