Govindhan Maduraiveeran* Pages 1 - 9 ( 9 )
Design of high-performance electrochemical sensor and biosensor platforms has attracted much devotion for the sensitive and selective detection of emergent biomarkers. Electrochemical sensor offers numerous advantageous features include cost-effective and ease of miniaturization, rapid and online monitoring, simultaneous detection ability, etc., which have captivated the potential interdisciplinary research. In this review, the advances and challenges towards the electrochemical detection of emergent biomarkers such as hydrogen peroxide, nitric oxide, β-nicotinamide adenine acetaminophen, dinucleotide (NADH) in biofluids are highlighted based on the recent research outcomes. In fact, the effective utility and benefits of transition metal nanocomposites without the utilization of biological materials, including enzymes, antibodies, etc. as electrode materials towards the detection of selected biomarkers in practical biofluids, monitoring early-stage and diagnosis of disease related biomarkers, are also described. These promising metal nanomaterials based electrochemical sensor platforms concrete the tactic for a new generation of sensing devices.
Biomarkers Detection, Electrochemical Sensor, Nanomaterials, Modified Electrode, Biomedical Application, hydrogen peroxide.
Department of Chemistry, Materials Electrochemistry Laboratory, SRM Institute of Science and Technology, SRM Nagar, Kattankulathur-603 203, Chennai, Tamil Nadu