Dan Qiao, Qiliang Deng* and Shuo Wang* Pages 1027 - 1036 ( 10 )
Background: The approach for the determination of aminoimidazo-azaarenes (AIAs) is urgently required due to their mutagenic activity and potential carcinogenicity. For this purpose, a CdSe/ZnS quantum dots (CdSe/ZnS QDs)-embedded molecularly imprinted silica gel with high selectivity and sensitivity was successfully prepared and applied to analyze such target.
Methods: Herein, CdSe/ZnS QDs acted as the fluorescent probe, and molecularly imprinted silica gel as a recognition probe was synthesized on the surface of QDs via sol-gel method. 2- Aminobenzimidazole, which has a similar structure with AIAs, as well as low cost and low toxicity, was selected as the dummy template.
Results: The material has a high imprinting factor (IF=6.15); the linear range of CdSe/ZnS@MIP as a fluorescent sensing material for AIAs is 0.5-20.0 μg L-1 with the limit of detection (LOD) of 0.25 μg L-1 (3σ/s). Moreover, the fluorescent materials have been further applied to determine AIAs in beef floss and grilled fish fillet with satisfactory recoveries (82.8-110.8 %), and the relative standard deviation (RSD) is < 5.5%.
Conclusion: The proposed CdSe/ZnS QDs-embedded molecularly imprinted silica gel can be used to easily and selectively detect AIAs.
Heterocyclic aromatic amines, fluorescence sensor, CdSe/ZnS quantum dots, molecularly imprinted silica gel, molecular imprinting, aminoimidazo-azaarenes.
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin, 300071, State Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300457, Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin, 300071