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High-Performance Liquid Chromatography Method for Simultaneous Determination of Bisphenols in Plastic Packed Dry Fruits Using Multiwalled Carbon Nanotubes as Solid Phase Extraction Sorbent

Author(s):

Hassan Y. Aboul-Enein*, Abdalla Ahmed Elbashir*, Mei Musa Ali Omar, Manahil Babiker Elamin and Shazalia Mahmoud Ahmed Ali   Pages 1 - 7 ( 7 )

Abstract:


Abstract Background: Bisphenols A (BPA), bisphenol S (BPS), and bisphenol F (BPF) are manufactured chemicals found in food packaging, drink containers, lotions, toys, plastic PVC flooring and water pipes. The aim of this work is to develop simple, rapid and reliable high-performance liquid chromatography with fluorescence detector (HPLC-FLD) method for simultaneous determination of bisphenols A (BPA), bisphenol F (BPF), and bisphenol S (BPS) in plastic packed dry fruits collected from Saudi Arabia markets. Methods: BPA, BPS and BPF in plastic packed dry fruits samples were extracted and clean up using packed Multi Walled Carbon Nanotubes (MWCNTs) mini-column followed by analysis using HPLC-FLD.

Results: The three BPs were separated within less than 12 min. The method was validated in terms of linearity, limit of detection (LOD), limit of quantification (LOQ), precision (repeatability) and accuracy (recovery). Good linearity was obtained in concentration range of 62.25-10000 μg/L for BPS and 6.25-1000 μg/L for BPA and BPF. The LODs and LOQs were found to be 1.07, 12.09, and 0.9939 μg/L and 3.56, 40.32 and 3.13 μg/L for bisphenols BPA, BPS, and BPF, respectively. Recoveries for analytes in the samples were all within the range of 87% to 104%.

Conclusion: The method was successfully applied to real dry fruit sample (i.e , dry date (Ajwa) , apricot, dry grapes and figs . The results obtained revealed that all of the tested BPs were present in the samples.

Keywords:

HPLC-FLD, Bisphenols, MWCNTs, SPE, plastic packed dry fruits

Affiliation:

Pharmaceutical and Medicinal Chemistry Department, Division of Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, University of Khartoum, Faculty of Science, Department of Chemistry, Khartoum, Sudan 11114, Central Laboratory, Ministry of Higher Education and Scientific Research, Khartoum, Department of Chemistry, Faculty of Science Al-Zulfi, Majmaah University,11952, Department of Chemistry, Faculty of Science Al-Zulfi, Majmaah University,11952



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