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Determination of Salicylic Acid Using a Highly Sensitive and New Electroanalytical Sensor

Author(s):

Maliheh Montazarolmahdi , Mahboubeh Masrournia* and Azizollah Nezhadali   Pages 1 - 8 ( 8 )

Abstract:


Background: A drug sensor (salicylic acid, in this case) was designed and made up of this research. The senor was made by modification of paste electrode (MPE) with CuO-SWCNTs and 1-hexyl-3-methylimidazolium chloride (HMICl). The MPE/CuO-SWCNTs/HMICl showed catalytic activity for the oxidation signal of salicylic acid in phosphate buffer solution.

Methods: Electrochemical methods were used as a powerful strategy for the determination of salicylic acid in pharmaceutical samples. Aiming at this goal, carbon paste electrode was amplified with conductive materials and used as a working electrode.

Results: The MPE/CuO-SWCNTs/HMICl was used for the determination of salicylic acid in the concentration range of 1.0 nM – 230 µM using differential pulse voltammetric (DPV) method. At pH=7.0, as optimum condition, the MPE/CuOSWCNTs/HMICl displayed a high-quality ability for the determination of salicylic acid in urine, pharmaceutical serum, and water samples.

Conclusion: The MPE/CuO-SWCNTs/HMICl was successfully used as a new and high performance working electrode for the determination of salicylic acid at a nanomolar level and in real samples.

Keywords:

Salicylic acid, CuO-SWCNTs, Electrochemical sensor, Ionic liquid, electroanalytical sensor, pharmaceutical samples.

Affiliation:

Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Department of Chemistry, Payame Noor University, 19395-4697, Tehran



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