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Fabrication of Electrochemical Sensor for Epinine Determination Amplified with MgO/CNTs Nanocomposite and Ionic Liquid


Shirin Shahraki, Mahboubeh Masrournia* and Hassan Karimi-Maleh   Pages 1 - 8 ( 8 )


Background: Catecholamines are a large group of pharmacological and biological compounds that are widely used in biological systems. These compounds are prepared both naturally and synthetically with many key roles in the human body and its activities. Therefore, many researchers focused on the identification and determination of catecholamines in biological samples.

Methods: MgO/SWCNTs were synthesized through the chemical precipitation method. In addition, cyclic voltammetry, differential pulse voltammetry, and chronoamperometric methods were used for the electro-oxidation reaction study of epinine at the surface of the modified electrode.

Results: Carbon paste electrode (CPE) modified with MgO/SWCNTs nanocomposite and 1-butyl- 3-methylimidazolium methanesulfonate (BMMS) was used as an electrochemical sensor for the determination of epinine. The results showed a linear dynamic range of 5.0 nM-250 μM with a detection limit of 0.1 nM for epinine determination using MgO/SWCNTs/BMMS/CPE as a sensor.

Conclusion: In the present study, a highly sensitive electrochemical sensor was designed and fabricated as an analytical tool for the determination of epinine. MgO/SWCNTs/BMMS/CPE was successfully used for the determination of epinine in water and dextrose saline with an acceptable recovery range of 98.7%-102.72%.


Epinine, MgO/SWCNTs, electrochemical sensor, ionic liquid, drug analysis, catecholamines.


Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Department of Chemical Engineering, Laboratory of Nanotechnology, Quchan University of Advanced Technology, Quchan

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