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Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry: A Review

[ Vol. 2 , Issue. 1 ]


Colin S. Creaser and Lucy Ratcliffe   Pages 9 - 15 ( 7 )


Atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) was first introduced in 1999. In the last few years, there has been a rapid growth in publications describing the development and application of APMALDI to the mass spectrometric analysis of peptides, polymers and oligosaccharides. This short review discusses recent advances in AP-MALDI, focusing on the analysis of biomolecules and the relative performance of MALDI at atmospheric pressure and in vacuo.


Atmospheric pressure, MALDI, Mass spectrometry


School of Biomedical and Natural Sciences, Interdisciplinary Biomedical Research Centre,Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK;

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