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Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionisation Mass Spectrometry: A Review

[ Vol. 2 , Issue. 1 ]

Author(s):

Colin S. Creaser and Lucy Ratcliffe   Pages 9 - 15 ( 7 )

Abstract:


Atmospheric pressure matrix-assisted laser desorption/ionization (AP-MALDI) was first introduced in 1999. In the last few years, there has been a rapid growth in publications describing the development and application of APMALDI to the mass spectrometric analysis of peptides, polymers and oligosaccharides. This short review discusses recent advances in AP-MALDI, focusing on the analysis of biomolecules and the relative performance of MALDI at atmospheric pressure and in vacuo.

Keywords:

Atmospheric pressure, MALDI, Mass spectrometry

Affiliation:

School of Biomedical and Natural Sciences, Interdisciplinary Biomedical Research Centre,Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK;



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