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Electrochemical Biosensors for Superoxide Anion

[ Vol. 2 , Issue. 1 ]

Author(s):

Yang Tian, Lanqun Mao and Takeo Ohsaka   Pages 51 - 58 ( 8 )

Abstract:


The determination of superoxide anion (O2 .-) is of great physiological and pathological importance since O2 .- is considered to be involved in the etiology of aging, cancer, and progressive neurodegenerative diseases such as Parkinsons disease. The determination of the local concentration of O2 .- has been a relatively challenging analytical problem because of the low concentration, high reactivity and short lifetime of O2 .- in biological systems. This review raises a number of methods, highlighting electrochemical methodologies, for the determination of O2 .-. These electrochemical sensors and biosensors and their analytical characteristics are discussed in detail.

Keywords:

Superoxide anion (O2), Electrochemical biosensors, Superoxide dismutase (SOD), Cytochrome c, Self-assembled monolayer (SAM), in vivo

Affiliation:

Department of Electronic Chemistry, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502, Japan;



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