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Microcantilever (MCL) Biosensing

[ Vol. 2 , Issue. 3 ]

Author(s):

Xiaodong Yan, Hai-Feng Ji and Thomas Thundat   Pages 297 - 307 ( 11 )

Abstract:


The analytical community continues to search for cost-effective, reliable, and even portable analytical techniques that can give reliable and fast-response results for a variety of biochemicals. Advances in the field of microelectro- mechanical systems (MEMS) and their uses now offer unique opportunities in the design of ultrasensitive analytical devices. Microcantilevers (MCLs) have been emerged as a novel unique platform for label-free biosensor or bioassay. This short review summarizes the biosensors using microcantilever (MCL) technology. DNA-based, antibody-based, enzyme- based, and membrane-based MCL sensors are discussed. The review is intended to provide an experts in this field an overview of MCL biosensors and to help the non-experts in the field to acquire a good understanding of the development of MCL biosensors and the main issues to be considered for further development of this biosensor technique.

Keywords:

Resonance frequency, Biosensors, DNA microarrays, DNA hybridization, Immobilization, mono-clonal antibody

Affiliation:

Institute for Micromanufacturing,Louisiana Tech. University, Ruston, LA 71272, USA.



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