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O-Benzyl-(S)-Serine, a New Chiral Selector for Ligand-Exchange Chromatography of Amino Acids

[ Vol. 1 , Issue. 1 ]


Benedetto Natalini, Roccaldo Sardella and Roberto Pellicciari   Pages 85 - 92 ( 8 )


O-Benzyl-(S)-serine is a new selector for chiral ligand-exchange chromatography which has proved to be effective in the analytical separation of some natural and unnatural underivatized amino acids with fair to good separation and resolution factors. Both chiral mobile phase (CMP) and hydrophobically coated chiral stationary phase (CSP) approaches were successfully employed. A not completely clarified mechanism of chiral recognition is discussed.


enantiomer separation, chiral mobile phase, chiral coated phase, hydrophobically coated phase


Universita degli Studi di Perugia, Dipartimento di Chimica e Tecnologia del Farmaco, Via del Liceo 1, 06123 Perugia, Italy.

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