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Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry

[ Vol. 5 , Issue. 2 ]

Author(s):

Willy Morelle   Pages 144 - 165 ( 22 )

Abstract:


The determination of post-translational modifications is one of the main challenges in proteomics research. Mass spectrometry is a powerful tool for the structural characterization of proteins and different mass spectrometric techniques for the analysis of post-translational modifications of individual proteins or protein populations have been developed. This review describes the most recent advances in mass spectrometry-based approaches for the detection and determination of post-translational modifications, with an emphasis on glycosylation and phosphorylation.

Keywords:

Mass spectrometry, Proteomics, Glycomics, Glycosylation, Phosphorylation, Glycoproteomics, Structural analysis

Affiliation:

Unite Mixte de Recherche CNRS/USTL 8576, Glycobiologie Structurale et Fonctionnelle, IFR 147, Batiment C9, Universite des Sciences et Technologies de Lille 1, 59655 Villeneuve d'Ascq Cedex, France.



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