Giuseppe Murdaca, Monica Greco, Simone Negrini, Marco Casciaro and Sebastiano Gangemi* Pages 283 - 290 ( 8 )
Human microbiota and immune system are strictly connected to each other. Several studies demonstrated that normal skin and/or gut floral alterations may have negative consequences on disease pathogenesis. Indeed, a strong association between skin and gut microbiota alterations and autoimmune diseases was found. Moreover, a significant interplay between microbiome and miRNAs expression was noticed among several conditions. The aim of this review article is to shed new light on some of the commonest skin disorders such as psoriasis, atopic dermatitis, allergic contact dermatitis, with special regard to epigenetic pathogenetic mechanisms such as miRNAs expression and skin and gut microbiome alterations. Indeed, evidence is still lacking regarding these two factors and their possible interactions. We believe their implications may be crucial for screening, early diagnosis and also therapeutic strategies; therefore, this field could represent a promising challenge for further studies.
Microbiome, skin, gut flora, autoimmune disorders, miRNAs , fungi.
Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino,Genoa, Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino,Genoa, Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino,Genoa, Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, Messina 98125, Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, Messina 98125