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AIE Luminogens as Versatile Bioprobes

[ Vol. 17 , Issue. 3 ]


Moustafa T. Gabr and F. Christopher Pigge*   Pages 302 - 316 ( 15 )


Background: Luminogens that feature aggregation induced emission (AIE) are typically non-emissive in solution but become highly luminescent upon aggregation in poor solvents or solid state.

Discussion: Unlike conventional fluorophores that exhibit aggregation-caused quenching (ACQ), utilization of AIE luminogens as bioprobes has featured superior photostability, low background signal, large Stokes’ shifts, high sensitivity and turn-on luminescent response.

Conclusion: The versatility of AIE-based luminogens as bioprobes has been demonstrated through various applications in cell organelle imaging, ion sensing and sensitive detection of biomacromolecules. Examples of AIE-based luminogens and their applications as luminescent sensors for biosensing and optical imaging are discussed herein.


Aggregation, bioprobes, fluorescence, luminescence, organelle imaging, sensors.


Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, Department of Chemistry, University of Iowa, Iowa City, Iowa 52242

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