Mustafa Çelebier and Ayşe Ercan* Pages 1 - 9 ( 9 )
Background: In this review an overview of the development of omics studies in recent years were considered. The bottom-up and top-down approaches on system biology were discussed and some of the recent tools that integrate multiomics data on system biology studies were discussed. The improvements on omics applications from genomics to metabolomics was inspected in the light of breast cancer biomarker discovery.
Results: It is known that genome or proteome analysis alone is not sufficient to elucidate the molecular mechanism of any disease, but instead, a holistic evaluation including metabolomics studies is rational and gives definite results. This review focused to present the studies performed on breast cancer biomarker development. Breast cancer markers approved in the beginning of the millennium encouraged researchers to search for diagnostic and prognostic biomarkers with the improvements of advanced analytical strategies. The recent developments on omics techniques and tools to process multi omics data are capable of presenting valuable scientific information better than ever before.
Conclusion: The clinical perspective of the researches using omics techniques might be supported with the integration of multiomics data to validate the results and to understand the molecular pathway interacted in the biological system.
Biological network, metabolic engineering, metabolomics, proteomics, system biology, Metabolic pathway analysis.
Department of Analytical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, Ankara