Maliheh Montazarolmahdi , Mahboubeh Masrournia* and Azizollah Nezhadali Pages 1 - 8 ( 8 )
Background: A drug sensor (salicylic acid, in this case) was designed and made up of this research. The senor was made by modification of paste electrode (MPE) with CuO-SWCNTs and 1-hexyl-3-methylimidazolium chloride (HMICl). The MPE/CuO-SWCNTs/HMICl showed catalytic activity for the oxidation signal of salicylic acid in phosphate buffer solution.
Methods: Electrochemical methods were used as a powerful strategy for the determination of salicylic acid in pharmaceutical samples. Aiming at this goal, carbon paste electrode was amplified with conductive materials and used as a working electrode.
Results: The MPE/CuO-SWCNTs/HMICl was used for the determination of salicylic acid in the concentration range of 1.0 nM – 230 µM using differential pulse voltammetric (DPV) method. At pH=7.0, as optimum condition, the MPE/CuOSWCNTs/HMICl displayed a high-quality ability for the determination of salicylic acid in urine, pharmaceutical serum, and water samples.
Conclusion: The MPE/CuO-SWCNTs/HMICl was successfully used as a new and high performance working electrode for the determination of salicylic acid at a nanomolar level and in real samples.
Salicylic acid, CuO-SWCNTs, Electrochemical sensor, Ionic liquid, electroanalytical sensor, pharmaceutical samples.
Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Department of Chemistry, Payame Noor University, 19395-4697, Tehran